2-Aminobenzothiazole derivatives: search for new antifungal agents.
نویسندگان
چکیده
A new series of 6-substituted 2-aminobenzothiazole derivatives were synthesized and screened in vitro as potential antimicrobials. Almost all the compounds showed antifungal activity. In particular, compounds 1n,o, designed on the basis of molecular modeling studies, were the best of the series, showing MIC values of 4-8 μg/mL against Candida albicans, Candida parapsilosis and Candida tropicalis. None of the two compounds did show any cytotoxicity effect on human THP-1 cells.
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ورودعنوان ژورنال:
- European journal of medicinal chemistry
دوره 64 شماره
صفحات -
تاریخ انتشار 2013